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Neurobiological Mechanisms in Postpartum Depression: Implications for Current and Future Treatments (Enduring)

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Postpartum depression (PPD), a biological complication of childbirth, is the most common and the most underdiagnosed postpartum complication, affecting 1 in 7 women. Numerous neuroendocrine mechanisms in the peripartum period, a time of abrupt and dramatic changes in hormone levels, have been identified and correlated with PPD. The withdrawal of reproductive hormones increases depression scores in women with a prior PPD history. Levels of GABA and neurosteroids are altered, whereas increased allopregnanolone levels have been shown to decrease the risk of PPD. This activity reviews the latest insights into the neurobiology of PPD and elucidates the mechanisms of action of the therapies in development as well as of currently approved therapy. 

Physicians: maximum of 1.50 AMA PRA Category 1 Credit(s)

Released: July 20, 2023

Expiration: July 20, 2024

No longer available for credit.

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Faculty

Crystal Clark

Crystal Clark, MD, MSc

Associate Professor of Psychiatry
Associate Head of Research
University of Toronto, Women’s College Hospital
Toronto, Canada

Tiffany A. Moore Simas

Tiffany A. Moore Simas, MD, MPH, MEd, FACOG

Professor of Obstetrics & Gynecology, Pediatrics, Psychiatry, and Population & Quantitative Health Sciences
Chair, Department of Obstetrics and Gynecology
UMass Chan Medical School
UMass Memorial Health
Worcester, Massachusetts

Lauren M. Osborne

Lauren M. Osborne, MD

(Program Chair)
Vice Chair for Clinical Research, Obstetrics & Gynecology
Weill Cornell Medicine
New York, New York

Acknowledgement

This activity is supported by an independent educational grant from Sage Therapeutics, Inc. and Biogen.

Provider Statement

Jointly provided by Partners for Advancing Clinical Education (PACE) and Miller Medical Communications, LLC.

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Target Audience

This activity is intended for health care professionals engaged in the care of patients with postpartum depression (PPD).

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Recognize the short- and long-term consequences of undiagnosed and untreated PPD

  • Describe key pathophysiological mechanisms implicated in PPD

  • Describe the safety and efficacy of existing and emerging therapies for PPD

  • Initiate treatment of women with suspected PPD and follow up appropriately to ensure continuity of care

Disclosure

PACE requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial relationships they may have with ineligible companies. All relevant financial relationships are thoroughly vetted and mitigated according to PACE policy. PACE is committed to providing learners with high-quality accredited CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The faculty reported the following financial relationships or relationships to products or devices they have with ineligible companies:

Lauren M. Osborne, MD (Program Chair) : Has nothing to disclose

Crystal T. Clark, MD, MSc: Consultant, Advisor, Speaker: Sage Therapeutics, Seven Starling

Tiffany A. Moore Simas, MD, MPH, MEd, FACOG: Consultant, Advisor, Speaker: ACOG, AIM, Beacon Health Options, MA Dept of Mental Health, MCPAP for Moms; Employee: UMass Memorial Health, UMass Chan Medical School; Executive Role: SASGOG; Researcher: ACOG, CDC, NIH, PCORI, Perigee Fund

The PACE planners and others have no relevant financial relationship(s) to disclose with ineligible companies. The Miller Medical Communications, LLC, planners and others have no relevant financial relationship(s) to disclose with ineligible companies.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Accreditation

Joint Accreditation Statement
Joint AccreditationIn support of improving patient care, this activity has been planned and implemented by Partners for Advancing Clinical Education (PACE) and Miller Medical Communications. PACE is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

 

Physician Continuing Medical Education
PACE designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Additional Information

Instructions for Credit

  1. There are no fees for participating in and receiving CME credit for this activity.
  2. During the period July 20, 2023, through July 20, 2024, participants must read the educational objectives and faculty disclosures and study the educational activity.
  3. If you wish to receive acknowledgment for completing this activity, please complete the post-test and evaluation.
  4. Upon registering and successfully completing the post-test with 3 out of 4 correct or better and activity evaluation, your certificate will be made available immediately.

Estimated time to complete activity: 1.5 hours